NXY-059 for acute ischemic stroke: the promise of neuroprotection is finally realized?
نویسنده
چکیده
منابع مشابه
A Critique of SAINT II: wishful thinking, dashed hopes, and the future of neuroprotection for acute stroke.
The neutral results of the SAINT II study1 dashed the hopes for a second ischemic stroke drug in the near future. Although this is certainly disappointing for stroke neurologists, a careful analysis of the NXY-059 development program reveals several deficiencies, which if properly addressed, might revitalize and strengthen the field of neuroprotection for acute ischemic stroke. This critique po...
متن کاملNXY-059 for acute ischemic stroke.
BACKGROUND NXY-059 is a free-radical-trapping agent that is neuroprotective in animal models of stroke. We tested whether it would reduce disability in humans after acute ischemic stroke. METHODS We conducted a randomized, double-blind, placebo-controlled trial involving 1722 patients with acute ischemic stroke who were randomly assigned to receive a 72-hour infusion of placebo or intravenous...
متن کاملNXY-059 for the treatment of acute stroke: pooled analysis of the SAINT I and II Trials.
BACKGROUND AND PURPOSE In animal models of acute ischemic stroke (AIS), the free radical-trapping agent NXY-059 showed promise as a neuroprotectant. SAINT I and II were randomized, placebo-controlled, double-blind trials to investigate the efficacy of NXY-059 in patients with AIS. METHODS Patients with AIS received an infusion of intravenous NXY-059 or placebo within 6 hours from the onset of...
متن کاملTolerability of NXY-059 at higher target concentrations in patients with acute stroke.
BACKGROUND AND PURPOSE NXY-059 is a nitrone-based free radical-trapping agent in development for acute stroke. In patients with acute stroke, NXY-059 is well tolerated at concentrations known to be associated with neuroprotection in animal models of transient cerebral ischemia; however, higher target concentrations appear necessary on the basis of animal models of permanent ischemia. METHODS ...
متن کاملCosmic implications of NXY-059.
The SAINT studies on NXY-0591,2 have reinvigorated debate over the momentous issues of neuroprotection and the development of novel stroke therapeutics. Some may argue there is little new ground that NXY-059 has unearthed and, in fact, the clinical trials merely confirm that as a strategy, neuroprotection has not been shown to be effective. Editorials in high-profile journals have sent out the ...
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ورودعنوان ژورنال:
- Stroke
دوره 37 10 شماره
صفحات -
تاریخ انتشار 2006